Matthew Perry’s Cause of Death Revealed

Friends star Matthew Perry’s shocking death was the result of “the acute effects of ketamine,” according to the toxicology report from the Los Angeles County Medical Examiner’s Office.

Per TMZ, Perry had taken ketamine infusion therapy for depression and anxiety roughly 10 days prior to his death. However, the report noted that “the ketamine in his system at death could not be from that infusion therapy, since ketamine’s half-life is 3 to 4 hours, or less.”

Listed as contributing factors in Perry’s death: drowning, coronary artery disease and buprenorphine effects (a medication used to treat opioid addiction).

There was reportedly no evidence of alcohol, methamphetamine, cocaine, heroin, PCP or fentanyl in Perry’s system at the time of his death, which was ruled accidental.

Perry died Saturday, Oct. 28 at the age of 54. The actor was discovered unresponsive in the jacuzzi at his Los Angeles-area home by his assistant. TMZ initially reported that his cause of death was drowning, until the case was later deferred pending the results of the toxicology report.

Two days later, Jennifer Aniston, Courteney Cox, Lisa Kudrow, LeBlanc and David Schwimmer reacted to Perry’s death with a joint statement. “We are all so utterly devastated by the loss of Matthew,” the quintet’s statement began. “We were more than just cast mates. We are a family. There is so much to say, but right now we’re going to take a moment to grieve and process this unfathomable loss.

“In time we will say more, as and when we are able,” the statement continued. “For now, our thoughts and our love are with Matty’s family, his friends, and everyone who loved him around the world.”

Friends co-creators Marta Kauffman and David Crane, and fellow EP Kevin Bright, also penned a tribute. “We are shocked and deeply, deeply saddened by our beloved friend Matthew’s passing,” the trio wrote on Oct. 29. “It still seems impossible. All we can say is that we feel blessed to have had him as part of our lives.”

GO ON, l-r: Matthew Perry, Laura Benanti in 'The World Ain't Over 'Til It's Over' (Season 1, Episode 11, aired December 4, 2012)

Matthew Perry’s Biggest TV Roles

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Perry’s role as Chandler on Friends, which ran from 1994 to 2004, made him and his costars household names. He was nominated for an Emmy in 2002 for Outstanding Lead Actor in a Comedy Series. He was nominated four other times, including twice for his guest work on The West Wing.

Additional TV credits included NBC’s Studio 60 on the Sunset Strip, CBS’ Odd Couple reboot and the short-lived sitcoms Mr. Sunshine (on ABC) and Go On (on NBC).

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